Plant Transcription Factor Database
Previous version: v3.0
Oryza sativa subsp. indica
HD-ZIP Family
Species TF ID Description
BGIOSGA026788-PAHD-ZIP family protein
BGIOSGA026973-PAHD-ZIP family protein
BGIOSGA008976-PAHD-ZIP family protein
BGIOSGA030941-PAHD-ZIP family protein
BGIOSGA014600-PAHD-ZIP family protein
BGIOSGA026851-PAHD-ZIP family protein
BGIOSGA032882-PAHD-ZIP family protein
BGIOSGA029665-PAHD-ZIP family protein
BGIOSGA006230-PAHD-ZIP family protein
BGIOSGA033443-PAHD-ZIP family protein
BGIOSGA032409-PAHD-ZIP family protein
BGIOSGA032818-PAHD-ZIP family protein
BGIOSGA016852-PAHD-ZIP family protein
BGIOSGA011366-PAHD-ZIP family protein
BGIOSGA022270-PAHD-ZIP family protein
BGIOSGA012175-PAHD-ZIP family protein
BGIOSGA022272-PAHD-ZIP family protein
BGIOSGA029853-PAHD-ZIP family protein
BGIOSGA008720-PAHD-ZIP family protein
BGIOSGA012017-PAHD-ZIP family protein
BGIOSGA001131-PAHD-ZIP family protein
BGIOSGA020603-PAHD-ZIP family protein
BGIOSGA026014-PAHD-ZIP family protein
BGIOSGA007547-PAHD-ZIP family protein
BGIOSGA011276-PAHD-ZIP family protein
BGIOSGA000239-PAHD-ZIP family protein
BGIOSGA020420-PAHD-ZIP family protein
BGIOSGA028102-PAHD-ZIP family protein
BGIOSGA014304-PAHD-ZIP family protein
BGIOSGA027698-PAHD-ZIP family protein
BGIOSGA005852-PAHD-ZIP family protein
BGIOSGA029405-PAHD-ZIP family protein
BGIOSGA000782-PAHD-ZIP family protein
BGIOSGA013211-PAHD-ZIP family protein
BGIOSGA035845-PAHD-ZIP family protein
BGIOSGA011687-PAHD-ZIP family protein
BGIOSGA021700-PAHD-ZIP family protein
BGIOSGA002186-PAHD-ZIP family protein
BGIOSGA014527-PAHD-ZIP family protein
BGIOSGA031343-PAHD-ZIP family protein
BGIOSGA033144-PAHD-ZIP family protein
BGIOSGA028396-PAHD-ZIP family protein
BGIOSGA004593-PAHD-ZIP family protein
HD-ZIP Family Introduction

A homeobox (HB) encodes a protein domain, the homeodomain (HD), which is a conserved 60-amino acid motif present in transcription factors found in all the eukaryotic organisms. This 60-amino acid sequence folds into a characteristic three-helix structure that is able to interact specifically with DNA. Most HDs are able to bind DNA as monomers with high affinity, through interactions made by helix III (the so-called recognition helix) and a disordered N-terminal arm located beyond helix I. The high degree of conservation of this type of domain among diverse proteins from different kingdoms indicates that this structure is crucial to maintain the HD functionality and that the role played by this domain is vital.

Members of the HD-Zip family have a leucine zipper motif (LZ) immediately downstream of the HD. The two motifs are present in transcription factors found in species belonging to other eukaryotic kingdoms, but their association in a single protein is unique to plants. The HD is responsible for the specific binding to DNA, whereas LZ acts as a dimerization motif. HD-Zip proteins bind to DNA as dimers, and the absence of LZ absolutely abolishes their binding ability, which indicates that the relative orientation of the monomers, driven by this motif, is crucial for an efficient recognition of DNA.

Ariel FD, Manavella PA, Dezar CA, Chan RL.
The true story of the HD-Zip family.
Trends Plant Sci, 2007. 12(9): p. 419-26.
PMID: 17698401